4-AcO-DMT (or psilacetin) is a semi-synthetic tryptamine closely related to the psychedelic mushroom molecules psilocin and psilocybin. In fact, 4-AcO-DMT is widely known as “synthetic mushrooms.” Like psilocybin, it appears that the body metabolizes 4-AcO-DMT into psilocin. Most people buy psilacetin as a brown or off-white powder that can be mixed with water just prior to dosing. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations.
True to its nickname, “synthetic mushrooms”, a 4-AcO-DMT experience is similar to a psilocybin trip. Its effects are dose-dependent, but mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.
Many factors contribute to the 4-AcO-DMT experience, including dose, mindset, setting, and method of consumption. With that in mind, each individual journey will be unique to the person, time, and place, and there’s no way to predict exactly what will happen. But, 4-AcO-DMT does induce some common experiences and effects that can help you prepare for your journey.
What to expect
The 4-AcO-DMT experience is often compared to that of psilocybin, but with a more mellow, euphoric sensibility. At high doses, 4-AcO-DMT is known for its vivid visionary effects, but moderate doses produce a visual experience similar to psilocybin, with objects appearing to breathe and wave. Many people who have taken 4-AcO-DMT say that while it can be more intense than mushrooms, it’s also more predictable.
A 4-AcO-DMT experience can last anywhere between two and eight hours, depending on how much you take and how it’s ingested. When taken orally, the effects of 4-AcO-DMT are usually felt within the first 45 minutes, with the peak lasting two to three hours and the comedown at least an hour. When insufflated the timeline of the entire experience is faster. During the peak, you can expect to experience feelings of euphoria, laughter, enhanced creativity and “flow,” introspective insights, an interest in usually mundane tasks, feelings of wonder and more. It’s also common to experience sensitivity to light, synesthesia, auditory hallucinations, increased or decreased emotional sensitivity, and time distortion, as well as less desirable effects such as over-stimulation,sweating/chills/flushing, aches, dizziness, anxiety and paranoia.
More extreme experiences can include an “additional layer” to reality, sometimes manifesting as an “energy field” around objects. Changes in perception of gravity or bodily sensations are also commonly reported. In addition to visual patterns, some people also experience “external” hallucinations, such as seemingly autonomous entities or spirits. At high doses, “ego-death” can occur, and many self-experimenters temporarily forget their own names. Like with many psychedelics, mystical-type experiences are also common, which could be beneficial to mental health.
Immediate after-effects of a 4-AcO-DMT experience—such as an afterglow—may last up to 48 hours.
Like psilocybin (4-PO-DMT), 4-AcO-DMT is an ester of psilocin (4-HO-DMT). The difference between the two is that psilocybin is the O-phosphorylated form, which naturally occurs in mushrooms; 4-AcO-DMT, on the other hand, is the O-acetylated form, hence the name O-Acetylpsilocin.In other words, 4-AcO-DMT has the same basic structure as both psilocin and psilocybin, but with an acetoxy group bonded to its indole ring.
Very little data exist on the receptor binding and metabolism of 4-AcO-DMT. Like psilocybin, it’s thought to be a prodrug of psilocin—in this case, deacetylated to psilocin during first-pass metabolism by the stomach and liver.With this in mind, we can assume that 4-AcO-DMT activates the 5-HT2A serotonin receptors, which is a similar mechanism of action as psilocybin and many other psychedelics.
However, some people have come to believe that 4-AcO-DMT may be more than just a prodrug of psilocin. There are many anecdotal reports of people injecting or smoking 4-AcO-DMT and experiencing nearly immediate psychoactivity (i.e. when bypassing first-pass metabolism). This suggests it may have its own pharmacodynamic profile and could account for some of the differences between the psilocybin and 4-AcO-DMT experiences.That said, it’s worth noting that naturally occurring psilocybin tends to be accompanied by other alkaloids that have their own effects, such as baeocystin and norbaeocystin—neither of which are present in 4-AcO-DMT powders.
Safety and toxicity
Taking into account the pharmacological similarities, we can assume that 4-AcO-DMT is just as safe and non-addictive as psilocybin/psilocin. Although clinical research is lacking—especially into its long-term effects and toxic overdose (if any)—anecdotal reports support its presumed safety. However, a number of 4-AcO-DMT trip reports report that very high doses can cause blackouts, vomiting, heart problems, hypertension, and seizures.No fatalities have been reported—at least in the absence of other drugs.
4-AcO-DMT is usually sold as a fumarate salt (a white-ish powder) containing on average 1 mg of pure 4-AcO-DMT for every 1.24 mg of powder.If it’s a hydrochloride salt, it will contain on average 1 mg of pure 4-AcO-DMT for every 1.15 mg of powder. In practice, the difference may be negligible, but it’s worth knowing. Given the prevalence of 4-AcO-DMT fumarate—and the fact that it contains less of the active indole alkaloid—it’s safe to assume dosage guidelines found online refer to the fumarate salt.
As a powder, 4-AcO-DMT is usually taken orally, but it can also be taken intranasally (snorted/insufflated). For other methods see FAQ. Either way, it’s processed more rapidly by the body than psilocybin mushrooms, typically resulting in a faster, more intense onset.
Even high-end doses are tiny, as with DMT, so you’ll need a digital milligram scale to weigh out your desired amount, based on the following ranges:
Oral 4-AcO-DMT dosage (in mg)
- Threshold: 2.5 – 5
- Light: 5 – 10
- Common: 10 – 25
- Strong: 25 – 40
- Heavy: 40+
Intranasal 4-AcO-DMT dosage (in mg)
- Threshold: <5
- Light: 5 – 10
- Common: 10 – 20
- Strong: 20 – 30
- Heavy: 30+